Thus, buspirone should not be recommended as a pharmacological option for dyspnea in cancer patients. Analysis of covariance (ANCOVA) controlling for baseline scores showed no statistically significant difference between groups for OCD (P = 0.052) or STAI-S (P = 0.062).Buspirone did not result in significant improvement in dyspnea or anxiety in cancer patients. Dyspnea was assessed by the Oxygen Cost Diagram (OCD higher scores are better) and anxiety by the state subscale of the State-Trait Anxiety Inventory (STAI-S lower scores are better) at baseline and after the 4-week intervention (post-intervention).Mean scores from baseline to post-intervention for buspirone were OCD 8.7 to 9.0 and STAI-S 40.5 to 40.1 and for placebo were OCD 8.4 to 9.3 and STAI-S 40.9 to 38.6 with raw improvements over time on both measures being greater in the placebo group. The main objective of our study was to evaluate whether buspirone alleviates dyspnea in cancer patients.We report on a randomized, placebo-controlled trial of 432 patients (mean age 64, female 51%, lung cancer 62%) from 16 participating Community Clinical Oncology Program (CCOP) sites with grade 2 or higher dyspnea, as assessed by the Modified Medical Research Council Dyspnea Scale. Buspirone, a non-benzodiazepine anxiolytic which does not suppress respiration and has proven efficacy in the treatment of generalized anxiety disorder, has been suggested to relieve the sensation of dyspnea in patients with COPD.
This study suggests that yoga is a promising intervention for music performance anxiety in conservatory students and therefore warrants further research.Ĭancer-related dyspnea is a common, distressing, and difficult-to-manage symptom in cancer patients, resulting in diminished quality of life and poor prognosis. Participants generally provided positive comments about the program and its benefits. Improvements were sustained at 7- to 14-month follow-up. Participants who completed the measures at both pre- and post-intervention assessments showed large decreases in music performance anxiety as well as in trait anxiety. Of the 24 students enrolled in the study, 17 attended the post-intervention assessment.
The intervention consisted of fourteen 60-minute yoga classes approximately twice a week and a brief daily home practice. This pilot study examined the effectiveness of a 9-week yoga practice on reducing music performance anxiety in undergraduate and graduate music conservatory students, including both vocalists and instrumentalists. There is a need for additional treatment strategies, especially those that might be more acceptable to musicians than existing therapies. Music performance anxiety can adversely affect musicians.
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